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Publication Date: 2009-12-18
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Pérez Cárdenas, J. E., Isaza Mejía, G., Acosta Agudelo, S. M., & Sepúlveda Arias, J. C. (2009). Preliminary test on the effects on the hematologic parameters of the aqueous and methanolic extracts of Phenax rugosus (poir.) Wedd and Tabebuia chrysantha G. Nicholson. Biosalud, 8, 17–28. Retrieved from https://ucaldas.metarevistas.org/index.php/biosalud/article/view/5520
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Abstract
In order to validate previous findings in ethnopharmacological studies, the effects on the hemogram of Wistar female rats after the oral administration of aqueous and methanolic extracts from Phenax rugosus (Poir.) Wedd and Tabebuia chrysantha G. Nicholson leaves were evaluated for 10 days. Except for the eosinophils count with the aqueous extract of Phenax rugosus (Poir.) Wedd, no significant changes in the hemogram were observed after the administration of aqueous and methanolic extracts. The absolute number of eosinophils diminished to statistically significant levels (p=0.03) when comparing the group that received the aqueous extract and the control group. The administration of both extracts from Tabebuia chrysantha G. Nicholson does not induce significant changes in the hemogram.
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References
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INVIMA, Ministerio de la Protección Social de Colombia (ed.) Normas Farmacológicas de la República de Colombia. 5a ed. Norma 23.1; 2006.
Böhler, T; Nolting, J; Gurragchaa, P; Lupescu, A; Neumayer, H.H.; Budde, K; Jamar, N; Klupp, J. Tabebuia avellanedae extracts inhibit IL-2-independent T-lymphocyte activation and proliferation. Transplant immunology 2008;18:319-323.
Sánchez, C; Gupta, M; Santana, AI. Actividad inmunomoduladora de las plantas (I). Revista de Fitoterapia 2002;2(2):151:163.
Oliveira-C, JF; Kiperstok, A.C; David, JP; David, JM, Giulietti, AM; Queiroz LP; Dos Santos, RR; Soares MBP. Anti-leishmanial and immunomodulatory activities of extracts from Portulaca hirsutissima and Portulaca werdermannii. Fitoterapia 2007;78:510-514.
Kovačević, N; Čolić, M; Backović, A; Došlov-Kokoruš, Z. Immunomodulatory effects of the methanolic extract of Epimedium alpinum in vitro. Fitoterapia 2006;77:561-567.
Potterat, O; Hamburger, M. Morinda citrifolia (Noni) fruti – phytochemistry, pharmacology, safety. Planta Med 2007;73(3):191-9.
Liu, J. The use of herbal medicines in early drug development for the treatment of HIV infections and AIDS. Expert Opin Investing Drugs 2007;16(9):1355-64.
Liu, JP; Manheimer, E; Yang, M. Herbal medicines for treating HIV infection and AIDS. Cochrane Database Syst Rev 2005;20(3):CD003937.
Bueno, JG; Isaza, G; Gutiérrez, F; Carmona, WD; Pérez, JE. Estudio etnofarmacológico de plantas usadas empíricamente por posibles efectos inmunoestimulantes. Rev. Med. Risaralda 2001;14:845-850.
Isaza, G; Bueno, JG; Jaramillo, R; Peñaloza, CA; Posso, CJ, Price, E; Rodríguez, GC. Estudio etnofarmacológico de plantas usadas empíricamente en 4 ciudades del centro-occidente colombiano. Medomai 2001;2(2):8-15.
Pérez, JE; Isaza, G; Bueno, JG; Arango, MC; Hincapié, BL, Nieto, AM; Londoño, DP. Efecto de los extractos de Phenax rugosus, Tabebuia chrysantha, Alternantera williamsi y Solanum dolichosepalum sobre el leucograma y la producción de anticuerpos en ratas. Rev. Med. Risaralda 2004;10:13-21.
Koyama, J; Morita, I; Tagahara, K; Hirai, K.I. Cyclopentene dialdehydes from Tabebuia impetiginosa. Phytochemesty 2000;53:869-872.
Steinert, J; Khalaf, H; Rimpler, M. HPLC separation and determination of naphtho [2,3- ß] furan – 4,9- diones and related compounds in extracts of Tabebuia avellanedae. Journal of Chromatography 1995;693:281-287.
Li, CJ; Averboukh, L; Pardee, AB. Beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin. Journal of Biological Chemestry 1993;268:22463-22468.
Son, DJ; Lim, Y; Park, YH; Chang, SK; Yun, Y-P; Hong, J-T; Takeoka, GR; Lee, K-G; Lee, S-E; Kim, M-R; Kim, J-H; Park, B-S. Inhibitory effects of Tabebuia impetiginosa inner bark extract on platelet aggregation and vascular smooth muscle cell proliferation through suppressions of arachidonic acid liberation and ERK ½ MAPK activation. Journal of Ethnopharmacology 2006;108:148-151.
Queiroz, MLS; Valadares, MC; Torello, CO; Ramos, AL; Oliveira, AB; Rocha, FD; Arruda, VA; Accorci, WR. Comparative studies of the effects of Tabebuia avellanedae bark extract and B-lapachone on the hematopoietic response of tumour-bearing mice. Journal of Ethnopharmacology 2008. 117:228-235.
NAPRALERT: Profile for Phenax rugosus 08/06/03.
Programa Iberoamericano de Ciencia y Tecnología. Actividad inmunomoduladora. En: Manual de técnicas de investigación. Santafé de Bogotá: CYTED; 1995. p. 105.
Zúñiga, JM; Tur, JA; Milocco, SN; Piñeiro, R. Vías de administración y obtención de fluidos. En: Zúñiga JM, Tur JA, Milocco SN, Piñeiro R., (ed). Ciencia y tecnología en protección y experimentación animal. 1a ed. España: McGraw-Hill / Interamericana; 2001. pp. 361-375.
Derechos Internacionales de los Animales. ONU y UNESCO. Citado el 10-11-2007. Disponible en: http://www.derechoanimal.es/2007/11/01/derechos-internacionales-de-los-animales/ http://www3.cricyt.edu.ar/mn/etica.htm. Consultado 10-11-2007..
Normas Científicas, Técnicas y Administrativas para la Investigación en Salud. Resolución No. 008430. Ministerio de Salud, División de Desarrollo Científico y Tecnológico. Santafé de Bogotá, D.C.: Ministerio de Salud; 1993.
Mrad, A; Cardozo, CA. Utilización de animales de laboratorio en la experimentación biológica. Universidad Nacional de Colombia, Instituto de Biotecnología. Bogotá D.C.: Universidad Nacional de Colombia; 2000.
Sher, A; Wynn, TA; Sacks, DL. The immune response to parasites. In: Paul, WE, ed. Fundamental Immunology. Fifth edition. New York: Lippincott Williams & Wilkins Publishers; 2003. pp. 2112-2166.
Leonard, WJ. Type I cytokines and interferons and their receptors. In: Paul, WE, ed. Fundamental Immunology. Fifth edition. New York: Lippincott Williams & Wilkins Publishers; 2003. pp. 1277-1278.
Medzhitoz, R. The innate immune system. In: Paul, WE, ed. Fundamental Immunology. Fifth edition. New York: Lippincott Williams & Wilkins Publishers; 2003. p. 57.
Hardy, RR. B-lymphocyte development and biology. In: Paul, WE, ed. Fundamental Immunology. Fifth edition. New York: Lippincott Williams & Wilkins Publishers; 2003. pp. 304-370.
Arango, M; Bueno, JG; Isaza, G; Pérez, JE; Álvarez, LF; Osorio, EJ; Rincón, AJ; Duque, AC. Efectos antibacterianos y antimicóticos de Alternanthera williamsii, Solanum dolichosepalum, Baccharis trinervis, Tabebuia chrysantha y Phenax rugosus. Biosalud 2004;3:49-54.
Secor Jr, E.R; Carson IV, W.F; Cloutier, M.M; Guernsey, L.A; Schramm, C.M; Wu, C.A; Thrall, R.S. Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease. Cellular immunology 2005;237:68-75.
Salgado H. Inmunofarmacología. En: Isaza CA, Isaza G, Fuentes J, Marulanda T., (ed). Fundamentos de Farmacología en Terapéutica. 5a ed. Pereira: Postergraph; 2008. pp. 459-472.
Sweetman, S.C. Immunosupressants. In: Sweetman, S.C, (ed). Martindale, The complete drug reference. 35th ed. Pharmaceutical Press: New York; 2007. pp. 1660-1689.
Kolodziej, H; Kiderlen, AF. In vitro evaluation of antibacterial and immunomodulatory activities of Pelargonium reniforme, Pelargonium sidoides and the related herbal drug preparation EPs 7630. Phytomedicine 2007;14(Suppl 6):18-26.
INVIMA, Ministerio de la Protección Social de Colombia (ed.) Normas Farmacológicas de la República de Colombia. 5a ed. Norma 23.1; 2006.
Böhler, T; Nolting, J; Gurragchaa, P; Lupescu, A; Neumayer, H.H.; Budde, K; Jamar, N; Klupp, J. Tabebuia avellanedae extracts inhibit IL-2-independent T-lymphocyte activation and proliferation. Transplant immunology 2008;18:319-323.
Sánchez, C; Gupta, M; Santana, AI. Actividad inmunomoduladora de las plantas (I). Revista de Fitoterapia 2002;2(2):151:163.
Oliveira-C, JF; Kiperstok, A.C; David, JP; David, JM, Giulietti, AM; Queiroz LP; Dos Santos, RR; Soares MBP. Anti-leishmanial and immunomodulatory activities of extracts from Portulaca hirsutissima and Portulaca werdermannii. Fitoterapia 2007;78:510-514.
Kovačević, N; Čolić, M; Backović, A; Došlov-Kokoruš, Z. Immunomodulatory effects of the methanolic extract of Epimedium alpinum in vitro. Fitoterapia 2006;77:561-567.
Potterat, O; Hamburger, M. Morinda citrifolia (Noni) fruti – phytochemistry, pharmacology, safety. Planta Med 2007;73(3):191-9.
Liu, J. The use of herbal medicines in early drug development for the treatment of HIV infections and AIDS. Expert Opin Investing Drugs 2007;16(9):1355-64.
Liu, JP; Manheimer, E; Yang, M. Herbal medicines for treating HIV infection and AIDS. Cochrane Database Syst Rev 2005;20(3):CD003937.
Bueno, JG; Isaza, G; Gutiérrez, F; Carmona, WD; Pérez, JE. Estudio etnofarmacológico de plantas usadas empíricamente por posibles efectos inmunoestimulantes. Rev. Med. Risaralda 2001;14:845-850.
Isaza, G; Bueno, JG; Jaramillo, R; Peñaloza, CA; Posso, CJ, Price, E; Rodríguez, GC. Estudio etnofarmacológico de plantas usadas empíricamente en 4 ciudades del centro-occidente colombiano. Medomai 2001;2(2):8-15.
Pérez, JE; Isaza, G; Bueno, JG; Arango, MC; Hincapié, BL, Nieto, AM; Londoño, DP. Efecto de los extractos de Phenax rugosus, Tabebuia chrysantha, Alternantera williamsi y Solanum dolichosepalum sobre el leucograma y la producción de anticuerpos en ratas. Rev. Med. Risaralda 2004;10:13-21.
Koyama, J; Morita, I; Tagahara, K; Hirai, K.I. Cyclopentene dialdehydes from Tabebuia impetiginosa. Phytochemesty 2000;53:869-872.
Steinert, J; Khalaf, H; Rimpler, M. HPLC separation and determination of naphtho [2,3- ß] furan – 4,9- diones and related compounds in extracts of Tabebuia avellanedae. Journal of Chromatography 1995;693:281-287.
Li, CJ; Averboukh, L; Pardee, AB. Beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin. Journal of Biological Chemestry 1993;268:22463-22468.
Son, DJ; Lim, Y; Park, YH; Chang, SK; Yun, Y-P; Hong, J-T; Takeoka, GR; Lee, K-G; Lee, S-E; Kim, M-R; Kim, J-H; Park, B-S. Inhibitory effects of Tabebuia impetiginosa inner bark extract on platelet aggregation and vascular smooth muscle cell proliferation through suppressions of arachidonic acid liberation and ERK ½ MAPK activation. Journal of Ethnopharmacology 2006;108:148-151.
Queiroz, MLS; Valadares, MC; Torello, CO; Ramos, AL; Oliveira, AB; Rocha, FD; Arruda, VA; Accorci, WR. Comparative studies of the effects of Tabebuia avellanedae bark extract and B-lapachone on the hematopoietic response of tumour-bearing mice. Journal of Ethnopharmacology 2008. 117:228-235.
NAPRALERT: Profile for Phenax rugosus 08/06/03.
Programa Iberoamericano de Ciencia y Tecnología. Actividad inmunomoduladora. En: Manual de técnicas de investigación. Santafé de Bogotá: CYTED; 1995. p. 105.
Zúñiga, JM; Tur, JA; Milocco, SN; Piñeiro, R. Vías de administración y obtención de fluidos. En: Zúñiga JM, Tur JA, Milocco SN, Piñeiro R., (ed). Ciencia y tecnología en protección y experimentación animal. 1a ed. España: McGraw-Hill / Interamericana; 2001. pp. 361-375.
Derechos Internacionales de los Animales. ONU y UNESCO. Citado el 10-11-2007. Disponible en: http://www.derechoanimal.es/2007/11/01/derechos-internacionales-de-los-animales/ http://www3.cricyt.edu.ar/mn/etica.htm. Consultado 10-11-2007..
Normas Científicas, Técnicas y Administrativas para la Investigación en Salud. Resolución No. 008430. Ministerio de Salud, División de Desarrollo Científico y Tecnológico. Santafé de Bogotá, D.C.: Ministerio de Salud; 1993.
Mrad, A; Cardozo, CA. Utilización de animales de laboratorio en la experimentación biológica. Universidad Nacional de Colombia, Instituto de Biotecnología. Bogotá D.C.: Universidad Nacional de Colombia; 2000.
Sher, A; Wynn, TA; Sacks, DL. The immune response to parasites. In: Paul, WE, ed. Fundamental Immunology. Fifth edition. New York: Lippincott Williams & Wilkins Publishers; 2003. pp. 2112-2166.
Leonard, WJ. Type I cytokines and interferons and their receptors. In: Paul, WE, ed. Fundamental Immunology. Fifth edition. New York: Lippincott Williams & Wilkins Publishers; 2003. pp. 1277-1278.
Medzhitoz, R. The innate immune system. In: Paul, WE, ed. Fundamental Immunology. Fifth edition. New York: Lippincott Williams & Wilkins Publishers; 2003. p. 57.
Hardy, RR. B-lymphocyte development and biology. In: Paul, WE, ed. Fundamental Immunology. Fifth edition. New York: Lippincott Williams & Wilkins Publishers; 2003. pp. 304-370.
Arango, M; Bueno, JG; Isaza, G; Pérez, JE; Álvarez, LF; Osorio, EJ; Rincón, AJ; Duque, AC. Efectos antibacterianos y antimicóticos de Alternanthera williamsii, Solanum dolichosepalum, Baccharis trinervis, Tabebuia chrysantha y Phenax rugosus. Biosalud 2004;3:49-54.
Secor Jr, E.R; Carson IV, W.F; Cloutier, M.M; Guernsey, L.A; Schramm, C.M; Wu, C.A; Thrall, R.S. Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease. Cellular immunology 2005;237:68-75.
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